Enantioresolution of fluorinated diphenylmethanols and determination of their absolute configurations by X-Ray crystallographic and 1H NMR anisotropy methods

Junpei Naito; Masashi Kosaka; Takeo Sugito; Masataka Watanabe; Nobuyuki Harada; William H Pirkle

doi:10.1002/chir.10302

Enantioresolution of fluorinated diphenylmethanols and determination of their absolute configurations by X-Ray crystallographic and 1H NMR anisotropy methods

Chirality. 2004 Jan;16(1):22-35. doi: 10.1002/chir.10302.

Authors

Junpei Naito¹, Masashi Kosaka, Takeo Sugito, Masataka Watanabe, Nobuyuki Harada, William H Pirkle

Affiliation

¹ Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, Sendai, Japan.

PMID: 14628296
DOI: 10.1002/chir.10302

Abstract

Various fluorinated diphenylmethanols were enantioresolved by the methods of chiral camphorsultam-dichlorophthalic acid (CSDP acid) and/or 2-methoxy-2-(1-naphthyl)propionic acid (MalphaNP acid) yielding enantiopure alcohols. Their absolute configurations were unambiguously determined by X-ray crystallography of CSDP esters and/or by the (1)H NMR anisotropy method of MalphaNP esters for the first time.