Abstract
We have detected an expressed mRNA encoding a splice variant of COX-1 in the mouse central nervous system. This isoform, referred to as COX-3, is identical in sequence to COX-1 except for the in-frame retention of intron 1. Like its counterpart COX-1, COX-3 does not generally appear to be induced by acute inflammatory stimulation.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Alternative Splicing / genetics*
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Animals
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Astrocytes / enzymology
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Base Sequence / genetics
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Brain / cytology
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Brain / enzymology*
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Cells, Cultured
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Cyclooxygenase 1
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DNA, Complementary / analysis
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DNA, Complementary / genetics
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Encephalitis / drug therapy
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Encephalitis / enzymology
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Encephalitis / genetics
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Introns / genetics
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Isoenzymes / genetics
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Membrane Proteins
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Mice
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Mice, Inbred C57BL
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Microglia / enzymology
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Molecular Sequence Data
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Neuroglia / cytology
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Neuroglia / enzymology*
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Neurons / cytology
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Neurons / enzymology*
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Prostaglandin-Endoperoxide Synthases / genetics*
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Protein Isoforms / genetics
Substances
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DNA, Complementary
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Isoenzymes
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Membrane Proteins
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Protein Isoforms
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Cyclooxygenase 1
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Prostaglandin-Endoperoxide Synthases
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Ptgs1 protein, mouse
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cyclooxygenase-3