COX-3: a splice variant of cyclooxygenase-1 in mouse neural tissue and cells

Brain Res Mol Brain Res. 2003 Nov 26;119(2):213-5. doi: 10.1016/j.molbrainres.2003.09.006.

Abstract

We have detected an expressed mRNA encoding a splice variant of COX-1 in the mouse central nervous system. This isoform, referred to as COX-3, is identical in sequence to COX-1 except for the in-frame retention of intron 1. Like its counterpart COX-1, COX-3 does not generally appear to be induced by acute inflammatory stimulation.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Alternative Splicing / genetics*
  • Animals
  • Astrocytes / enzymology
  • Base Sequence / genetics
  • Brain / cytology
  • Brain / enzymology*
  • Cells, Cultured
  • Cyclooxygenase 1
  • DNA, Complementary / analysis
  • DNA, Complementary / genetics
  • Encephalitis / drug therapy
  • Encephalitis / enzymology
  • Encephalitis / genetics
  • Introns / genetics
  • Isoenzymes / genetics
  • Membrane Proteins
  • Mice
  • Mice, Inbred C57BL
  • Microglia / enzymology
  • Molecular Sequence Data
  • Neuroglia / cytology
  • Neuroglia / enzymology*
  • Neurons / cytology
  • Neurons / enzymology*
  • Prostaglandin-Endoperoxide Synthases / genetics*
  • Protein Isoforms / genetics

Substances

  • DNA, Complementary
  • Isoenzymes
  • Membrane Proteins
  • Protein Isoforms
  • Cyclooxygenase 1
  • Prostaglandin-Endoperoxide Synthases
  • Ptgs1 protein, mouse
  • cyclooxygenase-3