Abstract
The capacity to generate a chronic and persistent infection in the experimental murine model of tuberculosis induced aerogenically by a low-dose inoculum was determined in eight isoniazid-resistant clinical strains of Mycobacterium tuberculosis showing different catalase-peroxidase (C-P) activities. Determination of bacillary concentration in lung and spleen and the percentage of pulmonary parenchyma occupied by granulomas were monitored. Data showed no relation between the lack of C-P activity and the ability to develop a persistent infection, highlighting the potential of C-P negative strains to spread through the community.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antitubercular Agents / therapeutic use
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Bacterial Proteins / metabolism*
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Disease Models, Animal
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Drug Resistance, Bacterial
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Female
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Genotype
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Isoniazid / therapeutic use
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Lung / microbiology
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Lung / pathology
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Male
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Mice
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Mice, Inbred C57BL
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Mycobacterium tuberculosis / drug effects
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Mycobacterium tuberculosis / enzymology*
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Mycobacterium tuberculosis / pathogenicity*
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Peroxidases / metabolism*
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Phenotype
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Spectrophotometry / methods
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Tuberculosis / enzymology
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Tuberculosis / microbiology*
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Tuberculosis / pathology
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Tuberculosis, Multidrug-Resistant / enzymology
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Tuberculosis, Multidrug-Resistant / microbiology*
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Tuberculosis, Pulmonary / enzymology
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Tuberculosis, Pulmonary / microbiology
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Tuberculosis, Pulmonary / pathology
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Virulence
Substances
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Antitubercular Agents
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Bacterial Proteins
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Peroxidases
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catalase-peroxidase, bacteria
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Isoniazid