Abstract
The ability to rapidly and reliably develop hypotheses on the function of newly discovered protein sequences requires systematic and comprehensive analysis. Such an analysis, embodied within the DS GeneAtlas pipeline, has been used to critically evaluate the severe acute respiratory syndrome (SARS) genome with the goal of identifying new potential targets for viral therapeutic intervention. This paper discusses several new functional hypotheses on the roles played by the constituent gene products of SARS, and will serve as an example of how such assignments can be developed or extended on other systems of interest.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Animals
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Binding Sites
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DNA Helicases / chemistry
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DNA Helicases / genetics
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DNA-Directed RNA Polymerases / chemistry
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DNA-Directed RNA Polymerases / genetics
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DNA-Directed RNA Polymerases / metabolism
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Genome, Viral*
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Humans
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Models, Molecular
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Molecular Sequence Data
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Protein Structure, Secondary
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RNA Helicases / chemistry
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RNA Helicases / genetics
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Sequence Alignment
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Sequence Analysis, Protein
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Sequence Homology, Amino Acid
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Severe acute respiratory syndrome-related coronavirus / chemistry
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Severe acute respiratory syndrome-related coronavirus / enzymology
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Severe acute respiratory syndrome-related coronavirus / genetics*
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Swine
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Transcription, Genetic
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Viral Proteins / chemistry*
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Viral Proteins / genetics*
Substances
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Viral Proteins
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DNA-Directed RNA Polymerases
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DNA Helicases
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RNA Helicases