Synthesis and biological evaluation of benzazepine oxazolidinone antibacterials

Bioorg Med Chem Lett. 2003 Dec 1;13(23):4197-200. doi: 10.1016/j.bmcl.2003.07.017.

Abstract

Novel benzazepine oxazolidinone antibacterials were synthesized and evaluated against clinically relevant susceptible and resistant organisms. The effect of ring nitrogen position and N-substitution on antibacterial activity is examined.

Publication types

  • Comparative Study

MeSH terms

  • Acetamides / pharmacology
  • Animals
  • Anti-Bacterial Agents / chemical synthesis*
  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / pharmacology*
  • Benzazepines / pharmacology*
  • Gram-Negative Bacteria / drug effects
  • Gram-Positive Bacteria / drug effects*
  • Linezolid
  • Mice
  • Microbial Sensitivity Tests
  • Oxazolidinones / chemical synthesis*
  • Oxazolidinones / chemistry
  • Oxazolidinones / pharmacology*
  • Structure-Activity Relationship

Substances

  • Acetamides
  • Anti-Bacterial Agents
  • Benzazepines
  • Oxazolidinones
  • Linezolid