Abstract
We compared the incorporation of bone allografts with or without vancomycin in tibial defects of 18 pigs. High-quality radiographs, histological examination, immunological expression of metalloproteinase-13 (MMP-13) and transforming growth factor-beta 2 (TGFbeta2) indicated that there was no significant difference in bone allograft incorporation between up to 220 times the MIC (minimum inhibitory concentration) in bone allografts with 1 g of vancomycin in each 300 g of allograft or without this supplement.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Bacterial Agents / administration & dosage*
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Bone Transplantation / pathology*
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Collagenases / metabolism
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Fibrosis
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Immunohistochemistry
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Male
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Matrix Metalloproteinase 13
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Necrosis
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Swine
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Tibia / pathology
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Tibia / transplantation
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Transforming Growth Factor beta / metabolism
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Transforming Growth Factor beta2
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Vancomycin / administration & dosage*
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Wound Healing / drug effects*
Substances
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Anti-Bacterial Agents
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Transforming Growth Factor beta
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Transforming Growth Factor beta2
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Vancomycin
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Collagenases
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Matrix Metalloproteinase 13