Incorporation of vancomycin-supplemented bone incorporation of vancomycin-supplemented bone allografts: radiographical, histopathological and immunohistochemical study in pigs

Acta Orthop Scand. 2003 Oct;74(5):505-13. doi: 10.1080/00016470310017884.

Abstract

We compared the incorporation of bone allografts with or without vancomycin in tibial defects of 18 pigs. High-quality radiographs, histological examination, immunological expression of metalloproteinase-13 (MMP-13) and transforming growth factor-beta 2 (TGFbeta2) indicated that there was no significant difference in bone allograft incorporation between up to 220 times the MIC (minimum inhibitory concentration) in bone allografts with 1 g of vancomycin in each 300 g of allograft or without this supplement.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Bacterial Agents / administration & dosage*
  • Bone Transplantation / pathology*
  • Collagenases / metabolism
  • Fibrosis
  • Immunohistochemistry
  • Male
  • Matrix Metalloproteinase 13
  • Necrosis
  • Swine
  • Tibia / pathology
  • Tibia / transplantation
  • Transforming Growth Factor beta / metabolism
  • Transforming Growth Factor beta2
  • Vancomycin / administration & dosage*
  • Wound Healing / drug effects*

Substances

  • Anti-Bacterial Agents
  • Transforming Growth Factor beta
  • Transforming Growth Factor beta2
  • Vancomycin
  • Collagenases
  • Matrix Metalloproteinase 13