[A case of hepatic metastasis and local recurrence from rectal cancer responding to hepatic arterial infusion and systemic chemotherapy]

Gan To Kagaku Ryoho. 2003 Oct;30(11):1729-32.
[Article in Japanese]

Abstract

A 71-year-old man underwent low anterior resection for rectal cancer. Two years after the surgery, liver metastasis and local recurrence were found on the CT scan. The first-line treatment was systemic chemotherapy (CPT-11 and 5'-DFUR). Effect was satisfactory for local recurrence, but a new liver tumor was found on the CT scan. The second-line treatment was a hepatic arterial infusion (5-FU) and systemic chemotherapy (UFT). After 4 courses, the liver metastasis was reduced, but after 5 courses, the liver tumors had enlarged. The third-line treatment was a hepatic arterial infusion (5-FU + levofolinate) and systemic chemotherapy (UFT). After 5 courses, the liver tumor disappeared, and no other recurrence was found on the CT scan.

Publication types

  • Case Reports

MeSH terms

  • Adenocarcinoma / drug therapy*
  • Adenocarcinoma / secondary
  • Aged
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
  • Camptothecin / administration & dosage
  • Camptothecin / analogs & derivatives*
  • Drug Administration Schedule
  • Drug Combinations
  • Floxuridine / administration & dosage
  • Fluorouracil / administration & dosage
  • Hepatic Artery
  • Humans
  • Infusions, Intra-Arterial
  • Irinotecan
  • Leucovorin / administration & dosage
  • Liver Neoplasms / drug therapy*
  • Liver Neoplasms / secondary
  • Male
  • Neoplasm Recurrence, Local / drug therapy*
  • Rectal Neoplasms / pathology*
  • Rectal Neoplasms / surgery
  • Tegafur / administration & dosage
  • Uracil / administration & dosage

Substances

  • Drug Combinations
  • UFT(R) drug
  • Floxuridine
  • Tegafur
  • Uracil
  • Irinotecan
  • Leucovorin
  • Fluorouracil
  • doxifluridine
  • Camptothecin