Total synthesis of the squalene synthase inhibitor zaragozic acid C by a carbonyl ylide cycloaddition strategy

Angew Chem Int Ed Engl. 2003 Nov 10;42(43):5351-5. doi: 10.1002/anie.200352629.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Azo Compounds / chemistry
  • Bridged Bicyclo Compounds, Heterocyclic / chemical synthesis*
  • Cyclization
  • Enzyme Inhibitors / chemical synthesis*
  • Farnesyl-Diphosphate Farnesyltransferase / antagonists & inhibitors*
  • Molecular Structure
  • Stereoisomerism
  • Tricarboxylic Acids / chemical synthesis

Substances

  • Azo Compounds
  • Bridged Bicyclo Compounds, Heterocyclic
  • Enzyme Inhibitors
  • Tricarboxylic Acids
  • zaragozic acid C
  • Farnesyl-Diphosphate Farnesyltransferase