The effect of chlorhexidine as an endodontic disinfectant

Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2003 Nov;96(5):578-81. doi: 10.1016/s1079-2104(03)00168-9.

Abstract

Objective: The purpose of this study was to establish whether addition of a 2% chlorhexidine rinse to a conventional treatment protocol enhances the rate of the successful disinfection of the root canal system in vivo.

Study design: Twenty-four teeth with infected necrotic pulps and resorbing apical periodontitis were treated with a conventional technique in which 1% NaOCl as irrigant was used. Half of the cases received an additional rinse with 2% chlorhexidine. Prereduced thioglycollate medium was used to take cultures that were incubated for 4 weeks.

Results: Cultivable bacteria were retrieved at the conclusion of the first visit in 1 out of 12 chlorhexidine cases whereas in the control group 7 out of 12 cases showed growth. This difference was significant (P < .05).

Conclusion: The findings are clinically important.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Anti-Infective Agents, Local / administration & dosage
  • Anti-Infective Agents, Local / therapeutic use*
  • Bacteria / growth & development
  • Calcium Hydroxide / therapeutic use
  • Chi-Square Distribution
  • Child
  • Chlorhexidine / administration & dosage
  • Chlorhexidine / therapeutic use*
  • Dental Pulp Cavity / drug effects
  • Dental Pulp Cavity / microbiology
  • Dental Pulp Necrosis / therapy
  • Disinfectants / administration & dosage
  • Disinfectants / therapeutic use
  • Drug Combinations
  • Follow-Up Studies
  • Humans
  • Middle Aged
  • Periapical Periodontitis / therapy
  • Root Canal Filling Materials / therapeutic use
  • Root Canal Irrigants / therapeutic use*
  • Single-Blind Method
  • Sodium Hypochlorite / administration & dosage
  • Sodium Hypochlorite / therapeutic use

Substances

  • Anti-Infective Agents, Local
  • Disinfectants
  • Drug Combinations
  • Root Canal Filling Materials
  • Root Canal Irrigants
  • Sodium Hypochlorite
  • Calcium Hydroxide
  • Chlorhexidine