Prenylated xanthones from Garcinia xanthochymus

Chem Pharm Bull (Tokyo). 2003 Nov;51(11):1332-4. doi: 10.1248/cpb.51.1332.

Abstract

A new prenylated xanthone, 1,3,5,6-tetrahydroxy-4,7,8-tri(3-methyl-2-butenyl)xanthone (1), was isolated from the wood of Garcinia xanthochymus together with a known xanthone, garciniaxanthone E (2). Their structures were determined by spectroscopic analysis. Compounds 1 (3 microM) and 2 (10 microM) elicited marked enhancement of nerve growth factor-mediated neurite outgrowth in PC12D cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Drug Synergism
  • Garcinia / chemistry*
  • Magnetic Resonance Spectroscopy
  • Nerve Growth Factors / pharmacology
  • Neurites / drug effects
  • PC12 Cells
  • Plant Extracts / chemistry
  • Protein Prenylation
  • Rats
  • Spectrometry, Mass, Electrospray Ionization
  • Spectrophotometry, Infrared
  • Spectrophotometry, Ultraviolet
  • Wood
  • Xanthones / chemistry*
  • Xanthones / isolation & purification
  • Xanthones / pharmacology

Substances

  • Nerve Growth Factors
  • Plant Extracts
  • Xanthones