Abstract
A new prenylated xanthone, 1,3,5,6-tetrahydroxy-4,7,8-tri(3-methyl-2-butenyl)xanthone (1), was isolated from the wood of Garcinia xanthochymus together with a known xanthone, garciniaxanthone E (2). Their structures were determined by spectroscopic analysis. Compounds 1 (3 microM) and 2 (10 microM) elicited marked enhancement of nerve growth factor-mediated neurite outgrowth in PC12D cells.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Drug Synergism
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Garcinia / chemistry*
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Magnetic Resonance Spectroscopy
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Nerve Growth Factors / pharmacology
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Neurites / drug effects
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PC12 Cells
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Plant Extracts / chemistry
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Protein Prenylation
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Rats
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Spectrometry, Mass, Electrospray Ionization
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Spectrophotometry, Infrared
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Spectrophotometry, Ultraviolet
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Wood
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Xanthones / chemistry*
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Xanthones / isolation & purification
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Xanthones / pharmacology
Substances
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Nerve Growth Factors
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Plant Extracts
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Xanthones