The importance of combining psychosocial and pharmacologic interventions for optimum outcome in the treatment of schizophrenia is now well recognized. However, less research is available on ways in which the two types of treatment may affect each other. This article reviews research and principles applying to the integrated use of current psychosocial and pharmacologic treatments for schizophrenia. Emphasis is placed on areas of interaction, including patient adherence and the effect of antipsychotic medications on cognitive functioning. Recommendations are presented for specific clinical situations.