Proteome analysis of mesencephalic tissues: evidence for Parkinson's disease

Neurol Sci. 2003 Oct;24(3):155-6. doi: 10.1007/s10072-003-0106-2.

Abstract

Proteome analysis is a powerful methodology to investigate protein expression in tissues involved in diseases not linked to particular genetic defects. To date, this technique has a limited number of applications in the field of neurodegenerative disorders. We decided therefore to investigate by this approach autoptic mesencephalic tissues of patients with idiopathic Parkinson's disease as well as control specimens from healthy subjects.

Publication types

  • Comparative Study

MeSH terms

  • Blotting, Western / methods
  • Databases, Protein
  • Dihydropteridine Reductase / metabolism
  • Electrophoresis, Gel, Two-Dimensional / methods
  • Humans
  • Nerve Tissue Proteins / metabolism
  • Parkinson Disease / diagnosis
  • Parkinson Disease / metabolism*
  • Proteome / analysis*
  • Substantia Nigra / chemistry*
  • Substantia Nigra / metabolism
  • Superoxide Dismutase / metabolism
  • Synucleins
  • Ubiquitin / metabolism
  • Ubiquitin-Protein Ligases / metabolism

Substances

  • Nerve Tissue Proteins
  • Proteome
  • Synucleins
  • Ubiquitin
  • Superoxide Dismutase
  • Dihydropteridine Reductase
  • Ubiquitin-Protein Ligases
  • parkin protein