Abstract
Three active glycosides that afford protection to red blood cell membrane to resist hemolysis induced by a peroxyl radical initiator, 2,2'-azo-bis-(2-amidinopropane) dihydrochloride (AAPH) were isolated from the MeOH extract of Ligustrum sinense. The compounds are 10-hydroxyl-oleuropein (1), 3-O-alpha-L-rhamnopyranosyl-kaempferol-7-O-beta-D-glucopyranoside (4), and 8'-alpha-hydroxyl-lariciresinol-4'-O-beta-D-glucopyranoside (6). The structures of these glycosides were determined by 1D and 2D NMR spectral analysis.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amidines / adverse effects
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Antioxidants / pharmacology*
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Cell Membrane
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Cyclopentane Monoterpenes
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Erythrocytes / physiology
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Glucosides / isolation & purification
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Glucosides / pharmacology*
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Guaiacol / analogs & derivatives
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Guaiacol / isolation & purification
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Guaiacol / pharmacology*
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Hemolysis
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Kaempferols / isolation & purification
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Kaempferols / pharmacology*
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Magnetic Resonance Spectroscopy
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Oleaceae / chemistry*
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Oxidants / adverse effects
Substances
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10-hydroxyoleuropein
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3-O-rhamnopyranosylkaempferol-7-O-glucopyranoside
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8'-hydroxylariciresinol-4'-O-glucopyranoside
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Amidines
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Antioxidants
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Cyclopentane Monoterpenes
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Glucosides
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Kaempferols
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Oxidants
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Guaiacol
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2,2'-azobis(2-amidinopropane)