Anti-oxidative activity of glycosides from Ligustrum sinense

Nat Prod Res. 2003 Dec;17(6):381-7. doi: 10.1080/1057563031000075476.

Abstract

Three active glycosides that afford protection to red blood cell membrane to resist hemolysis induced by a peroxyl radical initiator, 2,2'-azo-bis-(2-amidinopropane) dihydrochloride (AAPH) were isolated from the MeOH extract of Ligustrum sinense. The compounds are 10-hydroxyl-oleuropein (1), 3-O-alpha-L-rhamnopyranosyl-kaempferol-7-O-beta-D-glucopyranoside (4), and 8'-alpha-hydroxyl-lariciresinol-4'-O-beta-D-glucopyranoside (6). The structures of these glycosides were determined by 1D and 2D NMR spectral analysis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amidines / adverse effects
  • Antioxidants / pharmacology*
  • Cell Membrane
  • Cyclopentane Monoterpenes
  • Erythrocytes / physiology
  • Glucosides / isolation & purification
  • Glucosides / pharmacology*
  • Guaiacol / analogs & derivatives
  • Guaiacol / isolation & purification
  • Guaiacol / pharmacology*
  • Hemolysis
  • Kaempferols / isolation & purification
  • Kaempferols / pharmacology*
  • Magnetic Resonance Spectroscopy
  • Oleaceae / chemistry*
  • Oxidants / adverse effects

Substances

  • 10-hydroxyoleuropein
  • 3-O-rhamnopyranosylkaempferol-7-O-glucopyranoside
  • 8'-hydroxylariciresinol-4'-O-glucopyranoside
  • Amidines
  • Antioxidants
  • Cyclopentane Monoterpenes
  • Glucosides
  • Kaempferols
  • Oxidants
  • Guaiacol
  • 2,2'-azobis(2-amidinopropane)