Genetic relatedness of recently collected Spanish respiratory tract Streptococcus pneumoniae isolates with reduced susceptibility to amoxicillin

Antimicrob Agents Chemother. 2003 Nov;47(11):3637-9. doi: 10.1128/AAC.47.11.3637-3639.2003.

Abstract

Of Streptococcus pneumoniae isolates from 17 hospitals, 9.8% were amoxicillin nonsusceptible (MIC > or = 4 microg/ml). The genetic relatedness of 138 isolates was studied by pulsed-field gel electrophoresis. Although 44 different clones were detected, more than 62% of these isolates were related to four clones (Spain(23F)-1, Spain(6B)-2, Spain(9V)-3, and Spain(14)-5).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amoxicillin / pharmacology*
  • Cloning, Molecular
  • DNA, Bacterial / genetics
  • Drug Resistance, Bacterial
  • Drug Resistance, Multiple, Bacterial / genetics
  • Electrophoresis, Gel, Pulsed-Field
  • Humans
  • Microbial Sensitivity Tests
  • Penicillin Resistance / genetics*
  • Pneumococcal Infections / microbiology*
  • Respiratory Tract Infections / microbiology*
  • Reverse Transcriptase Polymerase Chain Reaction
  • Spain
  • Streptococcus pneumoniae / drug effects
  • Streptococcus pneumoniae / genetics*

Substances

  • DNA, Bacterial
  • Amoxicillin