A genome wide scan for association with multiple sclerosis in a N. Irish case control population

Shirley Heggarty; Stephen Sawcer; Stanley Hawkins; Gavin McDonnell; Aidan Droogan; Koen Vandenbroeck; Michael Hutchinson; Efrosini Setakis; Alastair Compston; Colin Graham

doi:10.1016/j.jneuroim.2003.08.019

A genome wide scan for association with multiple sclerosis in a N. Irish case control population

J Neuroimmunol. 2003 Oct;143(1-2):93-6. doi: 10.1016/j.jneuroim.2003.08.019.

Authors

Shirley Heggarty¹, Stephen Sawcer, Stanley Hawkins, Gavin McDonnell, Aidan Droogan, Koen Vandenbroeck, Michael Hutchinson, Efrosini Setakis, Alastair Compston, Colin Graham

Affiliation

¹ Regional Genetics Service, Belfast City Hospital, Belfast, UK.

PMID: 14575922
DOI: 10.1016/j.jneuroim.2003.08.019

Abstract

In order to screen the genome for linkage disequilibrium (LD) in multiple sclerosis (MS), we typed 2537 microsatellite markers in separately pooled DNA from 200 cases and 200 controls from N. Ireland. Twenty two markers showing significant evidence of association were identified including three from the HLA region on chromosome 6p21. Putative candidate genes mapping close to the 19 novel markers include the IL10RA and CD3E genes on 11q23 (which both lie close to the marker D11S1998). Individual typing of the marker D11S1998 confirmed its association.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Alleles
Case-Control Studies
Electrophoresis, Capillary / statistics & numerical data
Female
Gene Frequency
Genetic Predisposition to Disease*
Genetic Testing / methods*
Genetic Testing / statistics & numerical data
Genetics, Population / methods
Genetics, Population / statistics & numerical data
Genome, Human*
Genotype
Humans
International Cooperation
Male
Microsatellite Repeats
Multiple Sclerosis / epidemiology
Multiple Sclerosis / genetics*
Northern Ireland / epidemiology
Polymerase Chain Reaction / statistics & numerical data