Does tumor growth follow a "universal law"?

J Theor Biol. 2003 Nov 21;225(2):147-51. doi: 10.1016/s0022-5193(03)00221-2.

Abstract

A general model for the ontogenetic growth of living organisms has been recently proposed. Here we investigate the extension of this model to the growth of solid malignant tumors. A variety of in vitro and in vivo data are analysed and compared with the prediction of a "universal" law, relating properly rescaled tumor masses and tumor growth times. The results support the notion that tumor growth follows such a universal law. Several important implications of this finding are discussed, including its relevance for tumor metastasis and recurrence, cell turnover rates, angiogenesis and invasion.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Division
  • Computational Biology
  • Humans
  • Lymphatic Metastasis
  • Models, Biological
  • Neoplasm Invasiveness
  • Neoplasm Recurrence, Local / pathology
  • Neoplasms / pathology*
  • Neovascularization, Pathologic