Lactones from the leaves of Litsea japonica and their anti-complement activity

J Nat Prod. 2003 Oct;66(10):1388-90. doi: 10.1021/np030227i.

Abstract

Two new lactones, litsealactone A (1) and litsealactone B (2), were isolated from the leaves of Litsea japonica, together with three known lactones, hamabiwalactone A (3), hamabiwalactone B (4), and akolactone B (5). Hamabiwalactone B (4) and akolactone B (5) significantly inhibited complement activity in an in vitro anti-complement assay, with IC(50) values of 149 and 58 muM, respectively.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Complement Inactivator Proteins / chemistry
  • Complement Inactivator Proteins / isolation & purification*
  • Complement Inactivator Proteins / pharmacology
  • Inhibitory Concentration 50
  • Korea
  • Lactones / chemistry
  • Lactones / isolation & purification*
  • Lactones / pharmacology
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Plant Leaves / chemistry
  • Plants, Medicinal / chemistry*

Substances

  • Complement Inactivator Proteins
  • Lactones