Abstract
Natural and synthetic imino sugars are biologically important as glycosidase inhibitors. This review includes selected syntheses of 3-hydroxyproline, 4-hydroxyproline, 3,4-dihydroxyproline, 2-hydroxymethyl-3-hydroxypyrrolidine and 2-hydroxymethyl-pyrrolidine-3,4-diol, which exhibit glycosidase inhibitory and various other biological activities.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Arabinose
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Carbohydrates / chemistry
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Glycoside Hydrolases / antagonists & inhibitors
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Glycoside Hydrolases / metabolism
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Hydroxyproline / analogs & derivatives*
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Hydroxyproline / chemical synthesis*
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Hydroxyproline / chemistry
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Hydroxyproline / isolation & purification
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Imino Furanoses
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Stereoisomerism
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Sugar Alcohols / chemical synthesis*
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Sugar Alcohols / chemistry
Substances
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Carbohydrates
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Imino Furanoses
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Sugar Alcohols
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1,4-dideoxy-1,4-iminoarabinitol
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Arabinose
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Glycoside Hydrolases
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Hydroxyproline