Ionic liquid as a suitable phase for multistep parallel synthesis of an array of isoxazolines

Manuela Rodriquez; Alessandro Sega; Maurizio Taddei

doi:10.1021/ol035399l

Ionic liquid as a suitable phase for multistep parallel synthesis of an array of isoxazolines

Org Lett. 2003 Oct 30;5(22):4029-31. doi: 10.1021/ol035399l.

Authors

Manuela Rodriquez¹, Alessandro Sega, Maurizio Taddei

Affiliation

¹ Dipartimento Farmaco Chimico Tecnologico, Università degli Studi di Siena, Via A. Moro, 53100 Siena, Italy.

PMID: 14572241
DOI: 10.1021/ol035399l

Abstract

[reaction: see text]. A parallel array of isoxazoline diamides was prepared using an ionic liquid [bmim][BF4] as the phase where a three-step procedure (Schotten-Baumann, 1,3-dipolar cycloaddition, ester amidation with Me3Al) was carried out. At the end, selective extraction of the final products with diethyl ether allowed simple isolation of the 16 components of the array (Syncore technology).