Abstract
Renal units were created in vivo by transplanting isolated renal segments on three-dimensional, biodegradable polymer scaffolds. Renal segments, freshly isolated from rat kidneys, were seeded on polymer scaffolds and subcutaneously implanted in athymic mice for two and four weeks. Three-dimensional renal reconstructs were formed with glomeruli and tubules, showing a possibility of reconstituting renal structures by transplanting renal segments.
Publication types
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Evaluation Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Absorbable Implants*
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Animals
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Animals, Newborn
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Cell Division / physiology
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Culture Techniques / methods*
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Extracellular Matrix / physiology
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Graft Survival / physiology*
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Kidney / cytology*
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Kidney / growth & development*
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Kidney / surgery
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Kidney Transplantation / methods*
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Membranes, Artificial
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Polyglycolic Acid
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Rats
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Rats, Sprague-Dawley
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Regeneration / physiology*
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Tissue Engineering / methods*
Substances
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Membranes, Artificial
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Polyglycolic Acid