Percutaneous transluminal coronary angioplasty and stenting are established therapeutic modalities for coronary artery disease (CAD). Percutaneous transluminal septal myocardial ablation has become increasingly important for the treatment of symptomatic patients with hypertrophic obstructive cardiomyopathy (HOCM). We report a case of HOCM combined with CAD involving the left anterior descending coronary artery. Coronary stent graft implantation was performed with uneventful recovery. Coronary stent graft implantation may be beneficial in selected cases of symptomatic HOCM combined with CAD.