A group of Ti(60)Cu(14)Ni(12)Sn(4)M(10) (M=Nb, Ta, Mo) alloys was prepared using arc melting and copper mold casting. The as-prepared alloys have a composite microstructure containing a micrometer-sized dendritic beta-Ti(M) phase dispersed in a nanocrystalline matrix. These new alloys exhibit a low Young's modulus in the range of 59-103 GPa, and a high yield strength of 1037-1755 MPa, together with large plastic strains. The combination of high strength and low elastic modulus offers potential advantages in biomedical applications.