Fluorescent 2-pyrimidinone nucleoside in parallel-stranded DNA

Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug;22(5-8):1499-503. doi: 10.1081/ncn-120023020.

Abstract

Stretches of parallel-stranded (ps) double-helical DNA can arise within antiparallel-stranded (aps) Watson-Crick DNA in looped structures or in the presence of sequence mismatches. Here we studied an effect of a pyrimidinone-G (PG) base pair on the stability and conformation of the ps DNA to explore whether P is useful as a structural probe.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Base Pair Mismatch*
  • Base Pairing
  • Base Sequence
  • DNA / chemical synthesis*
  • DNA / chemistry
  • Deoxyribonucleosides / chemistry*
  • Fluorescent Dyes*
  • Nucleic Acid Conformation
  • Nucleic Acid Denaturation
  • Oligodeoxyribonucleotides / chemistry
  • Pyrimidinones*
  • Thermodynamics

Substances

  • Deoxyribonucleosides
  • Fluorescent Dyes
  • Oligodeoxyribonucleotides
  • Pyrimidinones
  • DNA