Oxidation of guanine nucleosides to 4-amidinocarbamoyl-5-hydroxyimidazoles by dimethyldioxirane

R Jeremy H Davies; Clarke Stevenson; Shiv Kumar; Jason Lyle; Lisa Cosby; John F Malone; Derek R Boyd; Narain D Sharma; Ann P Hunter; Bridget K Stein

doi:10.1081/NCN-120022964

Oxidation of guanine nucleosides to 4-amidinocarbamoyl-5-hydroxyimidazoles by dimethyldioxirane

Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug;22(5-8):1355-7. doi: 10.1081/NCN-120022964.

Authors

R Jeremy H Davies¹, Clarke Stevenson, Shiv Kumar, Jason Lyle, Lisa Cosby, John F Malone, Derek R Boyd, Narain D Sharma, Ann P Hunter, Bridget K Stein

Affiliation

¹ School of Biology and Biochemistry, Queen's University, Belfast, Northern Ireland. j.davies@qub.ac.uk

PMID: 14565417
DOI: 10.1081/NCN-120022964

Abstract

Final oxidation products generated from guanosine and 2'-deoxyguanosine by reaction with dimethyldioxirane have been identified as 4-amidinocarbamoyl-5-hydroxyimidazoles.

MeSH terms

Amidines
Deoxyguanosine / chemistry*
Epoxy Compounds
Guanosine / chemistry*
Imidazoles
Indicators and Reagents
Oxidation-Reduction

Substances

Amidines
Epoxy Compounds
Imidazoles
Indicators and Reagents
Guanosine
Deoxyguanosine
dimethyldioxirane