Conjugates of oligo(2'-O-methylribonucleotides) with minor groove binders as new sequence-specific agents recognizing both grooves of double-stranded DNA

D Novopashina; A Sinyakov; V Ryabinin; A Venyaminova; A Boutorine

doi:10.1081/NCN-120022830

Conjugates of oligo(2'-O-methylribonucleotides) with minor groove binders as new sequence-specific agents recognizing both grooves of double-stranded DNA

Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug;22(5-8):1179-82. doi: 10.1081/NCN-120022830.

Authors

D Novopashina¹, A Sinyakov, V Ryabinin, A Venyaminova, A Boutorine

Affiliation

¹ Novosibirsk Institute of Bioorganic Chemistry SB RAS, Novosibirsk, Russia. dasha@ngs.ru

PMID: 14565374
DOI: 10.1081/NCN-120022830

Abstract

Design, synthesis and physico-chemical studies of new pyrimidine oligo(2'-O-methylribonucleotide) conjugates with one or two oligo(pyrrolecarboxamide) minor groove binders (MGB) are described.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Base Sequence
Binding Sites
DNA / chemistry*
Indicators and Reagents
Nucleic Acid Conformation
Nucleic Acid Hybridization
Oligoribonucleotides / chemical synthesis*
Oligoribonucleotides / chemistry
Pyrimidines*

Substances

Indicators and Reagents
Oligoribonucleotides
Pyrimidines
DNA