Abstract
Novel halovinyl analogues of neplanocin A without 4'-hydroxymethyl group were easily synthesized starting from D-ribose via cyclopentenone 5 as a key intermediate and their inhibitory activity against SAH hydrolase was assayed.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adenine / analogs & derivatives*
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Adenine / chemical synthesis*
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Adenine / chemistry
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Adenine / pharmacology
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Adenosine / analogs & derivatives
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Adenosine / chemistry
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Adenosine / pharmacology
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Adenosylhomocysteinase / antagonists & inhibitors*
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Enzyme Inhibitors / chemical synthesis*
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Enzyme Inhibitors / chemistry
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Enzyme Inhibitors / pharmacology
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Molecular Structure
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Structure-Activity Relationship
Substances
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Enzyme Inhibitors
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neplanocin A
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Adenosylhomocysteinase
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Adenine
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Adenosine