Mononucleoside SATE glucosyl phosphorothiolates as a new series of pronucleotides

Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug;22(5-8):899-901. doi: 10.1081/NCN-120022681.

Abstract

The synthesis and the study of two phosphorothiolate derivatives of 3'-azido-2',3'-dideoxythymidine (AZT) bearing a S-pivaloyl-2-thioethyl (tBuSATE) group and glucosyl residues associated to the phosphorus atom by a 2-oxyethyl link, are reported. These derivatives could be considered as prototypes of a new series of nucleotide prodrugs (pronucleotides).

MeSH terms

  • Antiviral Agents / chemical synthesis*
  • Antiviral Agents / chemistry
  • Molecular Structure
  • Nucleosides / chemical synthesis*
  • Nucleosides / pharmacology
  • Prodrugs / chemical synthesis*
  • Prodrugs / chemistry
  • Zidovudine / analogs & derivatives
  • Zidovudine / chemical synthesis*
  • Zidovudine / chemistry

Substances

  • Antiviral Agents
  • Nucleosides
  • Prodrugs
  • Zidovudine