Abstract
The synthesis and the study of two phosphorothiolate derivatives of 3'-azido-2',3'-dideoxythymidine (AZT) bearing a S-pivaloyl-2-thioethyl (tBuSATE) group and glucosyl residues associated to the phosphorus atom by a 2-oxyethyl link, are reported. These derivatives could be considered as prototypes of a new series of nucleotide prodrugs (pronucleotides).
MeSH terms
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Antiviral Agents / chemical synthesis*
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Antiviral Agents / chemistry
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Molecular Structure
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Nucleosides / chemical synthesis*
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Nucleosides / pharmacology
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Prodrugs / chemical synthesis*
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Prodrugs / chemistry
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Zidovudine / analogs & derivatives
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Zidovudine / chemical synthesis*
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Zidovudine / chemistry
Substances
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Antiviral Agents
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Nucleosides
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Prodrugs
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Zidovudine