Abstract
A series of cyclohexenyl nucleosides (1-8) were successfully prepared with moderate yield and their cytotoxicity and antiviral activity were investigated. Among the eight new compounds, only the diaminopurine analogue 8 showed pronounced activity against HSV-1, HSV-2.
MeSH terms
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Antiviral Agents / chemical synthesis*
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Antiviral Agents / chemistry
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Antiviral Agents / pharmacology
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Cell Line
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Cell Survival / drug effects
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Cyclohexanes*
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Cytomegalovirus / drug effects
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Cytotoxins / chemical synthesis
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Cytotoxins / chemistry
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Cytotoxins / pharmacology
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Drug Design
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Herpesvirus 3, Human / drug effects
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Humans
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Nucleosides / chemical synthesis*
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Nucleosides / chemistry
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Nucleosides / pharmacology*
Substances
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Antiviral Agents
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Cyclohexanes
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Cytotoxins
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Nucleosides