Synthesis and biological evaluation of a series of new cyclohexenyl nucleosides

Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug;22(5-8):845-7. doi: 10.1081/NCN-120022668.

Abstract

A series of cyclohexenyl nucleosides (1-8) were successfully prepared with moderate yield and their cytotoxicity and antiviral activity were investigated. Among the eight new compounds, only the diaminopurine analogue 8 showed pronounced activity against HSV-1, HSV-2.

MeSH terms

  • Antiviral Agents / chemical synthesis*
  • Antiviral Agents / chemistry
  • Antiviral Agents / pharmacology
  • Cell Line
  • Cell Survival / drug effects
  • Cyclohexanes*
  • Cytomegalovirus / drug effects
  • Cytotoxins / chemical synthesis
  • Cytotoxins / chemistry
  • Cytotoxins / pharmacology
  • Drug Design
  • Herpesvirus 3, Human / drug effects
  • Humans
  • Nucleosides / chemical synthesis*
  • Nucleosides / chemistry
  • Nucleosides / pharmacology*

Substances

  • Antiviral Agents
  • Cyclohexanes
  • Cytotoxins
  • Nucleosides