4'-C-methyl-beta-D-ribofuranosyl purine and pyrimidine nucleosides revisited

J F Griffon; D Dukhan; C Pierra; S Benzaria; A G Loi; P La Colla; J P Sommadossi; G Gosselin

doi:10.1081/NCN-120022615

4'-C-methyl-beta-D-ribofuranosyl purine and pyrimidine nucleosides revisited

Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug;22(5-8):707-9. doi: 10.1081/NCN-120022615.

Authors

J F Griffon¹, D Dukhan, C Pierra, S Benzaria, A G Loi, P La Colla, J P Sommadossi, G Gosselin

Affiliation

¹ Laboratoire Coopératif Idenix-CNRS, Université Montpellier II, France.

PMID: 14565259
DOI: 10.1081/NCN-120022615

Abstract

In order to evaluate their antiviral properties, a series of 4'-C-methyl-beta-D-ribofuranosyl purine and pyrimidine nucleosides has been prepared. Unfortunately, none of these 4'-branched nucleosides showed any antiviral activity or cytotoxcity when tested against HIV, HBV, and Yellow Fever virus.

MeSH terms

Antiviral Agents / chemical synthesis
Drug Design
Indicators and Reagents
Methylation
Purine Nucleosides / chemical synthesis*
Purine Nucleosides / chemistry
Pyrimidine Nucleosides / chemical synthesis*
Pyrimidine Nucleosides / chemistry
Ribose

Substances

Antiviral Agents
Indicators and Reagents
Purine Nucleosides
Pyrimidine Nucleosides
Ribose