An evaluation of forward and inverse radiotherapy planning using Helax-TMS (version 6.0) for lung cancer patients treated with RTOG 93-11 dose-escalation protocol

Med Dosim. 2003 Fall;28(3):167-70. doi: 10.1016/S0958-3947(03)00067-0.

Abstract

This study investigated the dosimetric advantages of inversely planned intensity-modulated radiotherapy (IMRT) over forward-planned conventional 3D conformal radiotherapy (3D-CRT) in treating lung cancer patients at escalated dose. Three consecutively accrued patients on the RTOG 93-11 dose-escalation protocol were replanned using IMRT with the same dosimetric rules, so that the isodose distributions and dose-volume histograms could be generated and compared. The Helax-TMS treatment planning system, with an IMRT optimization module (version 6.0), was used. In all cases, a consistent approach of inverse planning and set of dose-volume constraints (DVCs) provided improved critical structure sparing. However, the minimum dose in PTV was generally below that achieved with the corresponding forward planned 3D-CRT.

MeSH terms

  • Algorithms*
  • Humans
  • Lung Neoplasms / radiotherapy*
  • Radiotherapy Dosage
  • Radiotherapy Planning, Computer-Assisted*
  • Radiotherapy, Conformal*