The evolution of a resistant pathogen--the case of MRSA

Mark C Enright

doi:10.1016/s1471-4892(03)00109-7

The evolution of a resistant pathogen--the case of MRSA

Curr Opin Pharmacol. 2003 Oct;3(5):474-9. doi: 10.1016/s1471-4892(03)00109-7.

Author

Mark C Enright¹

Affiliation

¹ Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, UK. m.c.enright@bath.ac.uk

PMID: 14559091
DOI: 10.1016/s1471-4892(03)00109-7

Abstract

Recent advances in molecular epidemiological methods have elucidated the evolutionary pathways by which modern methicillin-resistant Staphylococcus aureus have evolved. Only five major lineages of hospital methicillin-resistant Staphylococcus aureus exist, but these are globally distributed and evolving resistance to even the newest antibiotics.

Publication types

Review

MeSH terms

Animals
Community-Acquired Infections / drug therapy
Community-Acquired Infections / microbiology
Cross Infection / drug therapy
Cross Infection / microbiology
Evolution, Molecular
Humans
Methicillin Resistance / genetics*
Staphylococcal Infections / drug therapy
Staphylococcal Infections / microbiology*
Staphylococcus aureus / drug effects
Staphylococcus aureus / genetics*
Vancomycin Resistance / genetics