Abstract
We immunized mice with an attenuated (cold-adapted) influenza virus followed by an attenuated vaccinia virus (modified vaccinia virus Ankara), both expressing a CD8(+)-T-cell epitope derived from malaria sporozoites. This vaccination regimen elicited high levels of protection against malaria. This is the first time that the vaccine efficacy of a recombinant cold-adapted influenza virus vector expressing a foreign antigen has been evaluated.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adaptation, Physiological
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Animals
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Antibodies, Protozoan / blood
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CD8-Positive T-Lymphocytes / immunology*
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Cold Temperature
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Disease Models, Animal
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Epitopes, T-Lymphocyte / genetics
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Epitopes, T-Lymphocyte / immunology*
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Epitopes, T-Lymphocyte / metabolism
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Female
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Genetic Vectors
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Humans
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Immunization
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Immunization, Secondary
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Malaria / immunology
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Malaria / prevention & control*
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Malaria Vaccines / administration & dosage
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Malaria Vaccines / genetics
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Malaria Vaccines / immunology*
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Mice
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Mice, Inbred BALB C
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Orthomyxoviridae / genetics
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Orthomyxoviridae / immunology*
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Plasmodium yoelii / genetics
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Plasmodium yoelii / immunology*
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Protozoan Proteins / genetics
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Protozoan Proteins / immunology*
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Recombination, Genetic
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Vaccinia virus / genetics
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Vaccinia virus / immunology*
Substances
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Antibodies, Protozoan
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Epitopes, T-Lymphocyte
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Malaria Vaccines
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Protozoan Proteins
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circumsporozoite protein, Protozoan