Effect of pravastatin on coronary plaque volume

Am J Cardiol. 2003 Oct 15;92(8):975-7. doi: 10.1016/s0002-9149(03)00982-2.

Abstract

A volumetric analysis by 3-dimensional intravascular ultrasound revealed that lipid-lowering therapy with pravastatin significantly reduced coronary plaque volume. The changes in plaque volume were inversely correlated with the changes in plasma levels of high-density lipoprotein cholesterol but not with changes in levels of total cholesterol or low-density lipoprotein cholesterol.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Cholesterol, HDL / blood
  • Cholesterol, HDL / drug effects*
  • Cholesterol, LDL / blood
  • Cholesterol, LDL / drug effects*
  • Coronary Artery Disease / blood
  • Coronary Artery Disease / diagnostic imaging
  • Coronary Artery Disease / drug therapy*
  • Coronary Vessels / diagnostic imaging*
  • Female
  • Humans
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use*
  • Imaging, Three-Dimensional
  • Male
  • Middle Aged
  • Pravastatin / therapeutic use*
  • Treatment Outcome
  • Ultrasonography, Interventional

Substances

  • Cholesterol, HDL
  • Cholesterol, LDL
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors
  • Pravastatin