Objective: To report the use of tetracyclines for the treatment of multidrug-resistant Acinetobacter baumannii ventilator-associated pneumonia (VAP).
Design: Observational case series.
Setting: . The Presley Regional Trauma Center located within the Regional Medical Center, Memphis, Tennessee, USA.
Patients and participants: Seven critically ill trauma patients with VAP caused by A. baumannii isolates that were resistant to all antibiotics tested except for doxycycline or minocycline.
Interventions: Patients were treated with IV doxycycline or minocycline for an average of 13.5 (range 9-20) days.
Measurements and results: Doxycycline or minocycline was successful in six of seven patients.
Conclusions: Doxycycline or minocycline may be effective for treating multidrug-resistant A. baumannii VAP.