Tetracyclines for treating multidrug-resistant Acinetobacter baumannii ventilator-associated pneumonia

Intensive Care Med. 2003 Nov;29(11):2072-6. doi: 10.1007/s00134-003-1811-2. Epub 2003 Oct 11.

Abstract

Objective: To report the use of tetracyclines for the treatment of multidrug-resistant Acinetobacter baumannii ventilator-associated pneumonia (VAP).

Design: Observational case series.

Setting: . The Presley Regional Trauma Center located within the Regional Medical Center, Memphis, Tennessee, USA.

Patients and participants: Seven critically ill trauma patients with VAP caused by A. baumannii isolates that were resistant to all antibiotics tested except for doxycycline or minocycline.

Interventions: Patients were treated with IV doxycycline or minocycline for an average of 13.5 (range 9-20) days.

Measurements and results: Doxycycline or minocycline was successful in six of seven patients.

Conclusions: Doxycycline or minocycline may be effective for treating multidrug-resistant A. baumannii VAP.

MeSH terms

  • APACHE
  • Acinetobacter Infections* / drug therapy
  • Acinetobacter Infections* / etiology
  • Acinetobacter Infections* / mortality
  • Acinetobacter baumannii*
  • Adolescent
  • Adult
  • Aged
  • Anti-Bacterial Agents / therapeutic use*
  • Bronchoalveolar Lavage Fluid / microbiology
  • Critical Care / methods
  • Critical Illness
  • Cross Infection* / drug therapy
  • Cross Infection* / etiology
  • Cross Infection* / mortality
  • Doxycycline / therapeutic use*
  • Drug Resistance, Multiple, Bacterial
  • Humans
  • Infection Control / methods
  • Infusions, Intravenous
  • Microbial Sensitivity Tests
  • Middle Aged
  • Minocycline / therapeutic use*
  • Pneumonia, Bacterial* / drug therapy
  • Pneumonia, Bacterial* / etiology
  • Pneumonia, Bacterial* / mortality
  • Respiration, Artificial / adverse effects*
  • Retrospective Studies
  • Tennessee / epidemiology
  • Trauma Centers
  • Treatment Outcome

Substances

  • Anti-Bacterial Agents
  • Minocycline
  • Doxycycline