Growth inhibition activity of thioacetal artemisinin derivatives against human umbilical vein endothelial cells

Bioorg Med Chem Lett. 2003 Nov 3;13(21):3665-8. doi: 10.1016/j.bmcl.2003.08.023.

Abstract

Thioacetal artemisinin derivatives, in particular, 10alpha-phenylthiodihydroartemisinins (5), 10beta-benzenesulfonyl-9-epi-dihydroartemisinin (9) and 10alpha-mercaptodihydroartemisinin (11), exhibit good growth inhibition activity against HUVEC proliferation at the concentration level of 1 microM.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetals / chemical synthesis*
  • Acetals / pharmacology
  • Artemisinins / chemical synthesis*
  • Artemisinins / pharmacology
  • Cell Division / drug effects
  • Colorimetry
  • Endothelial Cells / drug effects*
  • Female
  • Humans
  • Lactones / chemical synthesis*
  • Lactones / pharmacology
  • Pregnancy
  • Sesquiterpenes / chemical synthesis*
  • Sesquiterpenes / pharmacology
  • Structure-Activity Relationship
  • Tetrazolium Salts
  • Thiazoles
  • Umbilical Veins / cytology
  • Umbilical Veins / drug effects

Substances

  • Acetals
  • Artemisinins
  • Lactones
  • Sesquiterpenes
  • Tetrazolium Salts
  • Thiazoles
  • thiazolyl blue
  • artemisin