Abstract
Recent studies in Caenorhabditis elegans implicate PcG- and NuRD-like chromatin regulators in the establishment and maintenance of germline-soma distinctions. Somatic cells appear to utilize NuRD-related nucleosome-remodeling factors to overwrite germline-specific chromatin states that are specified through PcG-like activities. The germline, in turn, may rely on an asymmetrically inherited inhibitor to prevent chromatin reorganization that would otherwise erase pluripotency.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Caenorhabditis elegans / embryology
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Caenorhabditis elegans / genetics*
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Caenorhabditis elegans Proteins / genetics
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Caenorhabditis elegans Proteins / metabolism
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Chromatin / physiology*
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Gene Expression Regulation, Developmental / physiology*
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Germ Cells / growth & development
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Germ Cells / metabolism*
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Nuclear Proteins / genetics
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Nuclear Proteins / metabolism
Substances
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Caenorhabditis elegans Proteins
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Chromatin
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Nuclear Proteins
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pie-1 protein, C elegans