Rapid and efficient synthesis of 1H-indol-2-yl-1H-quinolin-2-ones

Jeffrey T Kuethe; Audrey Wong; Ian W Davies

doi:10.1021/ol035541i

Rapid and efficient synthesis of 1H-indol-2-yl-1H-quinolin-2-ones

Org Lett. 2003 Oct 16;5(21):3975-8. doi: 10.1021/ol035541i.

Authors

Jeffrey T Kuethe¹, Audrey Wong, Ian W Davies

Affiliation

¹ Department of Process Research, Merck & Co., Inc., P.O. Box 2000, Rahway, New Jersey 07065, USA.

PMID: 14535757
DOI: 10.1021/ol035541i

Abstract

[reaction: see text] A concise and efficient synthesis of the novel indol-2-yl-1H-quinolin-2-one ring system found in the potent and selective KDR kinase inhibitors 1-3 is presented.