Implantable drug-releasing biodegradable microspheres for local treatment of brain glioma

Acta Neurochir Suppl. 2003:88:51-5. doi: 10.1007/978-3-7091-6090-9_9.

Abstract

Our group have developed a new method of drug delivery into the brain using implantable biodegradable microspheres. In this mini-review, we describe the development, preclinical studies and clinical trials involving 5-fluorouracil-releasing microspheres for interstitial radiosensitization of malignant glioma. Future developments concerning these microspheres for treatment of brain tumors are presented.

Publication types

  • Clinical Trial
  • Clinical Trial, Phase I
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Animals
  • Antineoplastic Agents / administration & dosage*
  • Antineoplastic Agents / pharmacokinetics
  • Biological Availability
  • Brain Neoplasms / drug therapy*
  • Brain Neoplasms / mortality
  • Brain Neoplasms / radiotherapy
  • Brain Neoplasms / surgery
  • Combined Modality Therapy
  • Female
  • Fluorouracil / administration & dosage*
  • Fluorouracil / pharmacokinetics
  • Glioblastoma / drug therapy*
  • Glioblastoma / mortality
  • Glioblastoma / radiotherapy
  • Glioblastoma / surgery
  • Humans
  • Male
  • Metabolic Clearance Rate / physiology
  • Mice
  • Microspheres
  • Middle Aged
  • Neoadjuvant Therapy*
  • Pilot Projects
  • Radiation-Sensitizing Agents / administration & dosage*
  • Radiation-Sensitizing Agents / pharmacokinetics
  • Stereotaxic Techniques
  • Survival Rate

Substances

  • Antineoplastic Agents
  • Radiation-Sensitizing Agents
  • Fluorouracil