Abstract
Our group have developed a new method of drug delivery into the brain using implantable biodegradable microspheres. In this mini-review, we describe the development, preclinical studies and clinical trials involving 5-fluorouracil-releasing microspheres for interstitial radiosensitization of malignant glioma. Future developments concerning these microspheres for treatment of brain tumors are presented.
Publication types
-
Clinical Trial
-
Clinical Trial, Phase I
-
Randomized Controlled Trial
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Adolescent
-
Adult
-
Aged
-
Animals
-
Antineoplastic Agents / administration & dosage*
-
Antineoplastic Agents / pharmacokinetics
-
Biological Availability
-
Brain Neoplasms / drug therapy*
-
Brain Neoplasms / mortality
-
Brain Neoplasms / radiotherapy
-
Brain Neoplasms / surgery
-
Combined Modality Therapy
-
Female
-
Fluorouracil / administration & dosage*
-
Fluorouracil / pharmacokinetics
-
Glioblastoma / drug therapy*
-
Glioblastoma / mortality
-
Glioblastoma / radiotherapy
-
Glioblastoma / surgery
-
Humans
-
Male
-
Metabolic Clearance Rate / physiology
-
Mice
-
Microspheres
-
Middle Aged
-
Neoadjuvant Therapy*
-
Pilot Projects
-
Radiation-Sensitizing Agents / administration & dosage*
-
Radiation-Sensitizing Agents / pharmacokinetics
-
Stereotaxic Techniques
-
Survival Rate
Substances
-
Antineoplastic Agents
-
Radiation-Sensitizing Agents
-
Fluorouracil