Abstract
Surgical material of the lungs and their parts from 31 patients and open biopsies were studied. Proliferative activity (Ki-67, PCNA) and oncomarkers expression (bcl-2, p-53, c-myc, b-TGF, chromogranin-A) were studied immunohistochemically in the foci of various epithelial changes. It is established that a wide spectrum of alterations in pulmonary tissue is associated with variability of precursor cells and may have nosological features.
MeSH terms
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Adolescent
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Adult
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Aged
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Biomarkers, Tumor / biosynthesis*
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Chronic Disease
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Female
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Humans
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Immunohistochemistry
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Ki-67 Antigen / biosynthesis
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Lung / metabolism
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Lung / pathology*
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Lung / surgery
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Lung Diseases / metabolism
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Lung Diseases / pathology*
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Lung Diseases / surgery
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Lung Neoplasms / metabolism
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Lung Neoplasms / pathology*
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Male
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Middle Aged
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Precancerous Conditions / metabolism
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Precancerous Conditions / pathology*
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Proliferating Cell Nuclear Antigen / biosynthesis
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Proto-Oncogene Proteins c-bcl-2 / biosynthesis
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Respiratory Mucosa / metabolism
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Respiratory Mucosa / pathology*
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Tumor Suppressor Protein p53 / biosynthesis
Substances
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Biomarkers, Tumor
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Ki-67 Antigen
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Proliferating Cell Nuclear Antigen
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Proto-Oncogene Proteins c-bcl-2
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Tumor Suppressor Protein p53