Abstract
Peptide carbamates containing the sequence H-Pro-Trp-PheNH2 showed in CDCl3 restricted conformations stabilized by the presence of a gamma-turn. To test the reliability of the peptides as endomorphin conformational models, we measured the affinities for mu-receptors labelled with [3H]-DAMGO. In particular, Cbz-Pro-Trp-PheNH2 displayed a nanomolar affinity.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Carbamates / chemistry
-
Carbamates / pharmacology
-
Ligands
-
Magnetic Resonance Spectroscopy
-
Oligopeptides / chemical synthesis
-
Oligopeptides / chemistry*
-
Oligopeptides / pharmacology
-
Protein Conformation
-
Rats
-
Receptors, Opioid, mu / drug effects*
-
Solvents / chemistry
-
Spectrophotometry, Infrared
-
Temperature
Substances
-
Carbamates
-
Ligands
-
Oligopeptides
-
Receptors, Opioid, mu
-
Solvents
-
endomorphin 1