Pyrocoll, an antibiotic, antiparasitic and antitumor compound produced by a novel alkaliphilic Streptomyces strain

J Antibiot (Tokyo). 2003 Jul;56(7):639-46. doi: 10.7164/antibiotics.56.639.

Abstract

A new secondary metabolite was detected in the culture extract of Streptomyces sp. AK 409 by HPLC-diode-array screening. The metabolite was identified as pyrocoll, which is known to be a constituent of cigarette smoke. Pyrocoll is known as a synthetic compound, but until now had not been isolated as a natural product from a microorganism. The compound showed biological activity against various Arthrobacter strains, filamentous fungi, several pathogenic protozoa, and some human tumor cell lines.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antibiotics, Antineoplastic / chemistry
  • Antibiotics, Antineoplastic / isolation & purification*
  • Antibiotics, Antineoplastic / pharmacology
  • Antiprotozoal Agents / chemistry
  • Antiprotozoal Agents / isolation & purification*
  • Antiprotozoal Agents / pharmacology
  • Chromatography, Gel
  • Chromatography, High Pressure Liquid
  • Drug Screening Assays, Antitumor
  • Fermentation
  • HeLa Cells
  • Humans
  • Mass Spectrometry
  • Mice
  • Microbial Sensitivity Tests
  • Nuclear Magnetic Resonance, Biomolecular
  • Pyrroles / isolation & purification*
  • Pyrroles / pharmacology
  • Soil Microbiology
  • Spectrophotometry, Infrared
  • Streptomyces / chemistry
  • Streptomyces / metabolism*

Substances

  • Antibiotics, Antineoplastic
  • Antiprotozoal Agents
  • Pyrocoll
  • Pyrroles