Abstract
A new secondary metabolite was detected in the culture extract of Streptomyces sp. AK 409 by HPLC-diode-array screening. The metabolite was identified as pyrocoll, which is known to be a constituent of cigarette smoke. Pyrocoll is known as a synthetic compound, but until now had not been isolated as a natural product from a microorganism. The compound showed biological activity against various Arthrobacter strains, filamentous fungi, several pathogenic protozoa, and some human tumor cell lines.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antibiotics, Antineoplastic / chemistry
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Antibiotics, Antineoplastic / isolation & purification*
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Antibiotics, Antineoplastic / pharmacology
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Antiprotozoal Agents / chemistry
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Antiprotozoal Agents / isolation & purification*
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Antiprotozoal Agents / pharmacology
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Chromatography, Gel
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Chromatography, High Pressure Liquid
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Drug Screening Assays, Antitumor
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Fermentation
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HeLa Cells
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Humans
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Mass Spectrometry
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Mice
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Microbial Sensitivity Tests
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Nuclear Magnetic Resonance, Biomolecular
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Pyrroles / isolation & purification*
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Pyrroles / pharmacology
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Soil Microbiology
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Spectrophotometry, Infrared
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Streptomyces / chemistry
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Streptomyces / metabolism*
Substances
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Antibiotics, Antineoplastic
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Antiprotozoal Agents
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Pyrocoll
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Pyrroles