Saponins from Cussonia bancoensis and their inhibitory effects on nitric oxide production

J Nat Prod. 2003 Sep;66(9):1266-9. doi: 10.1021/np020412g.

Abstract

Two new triterpenoid saponins (1 and 2) were isolated from the stem bark of Cussonia bancoensis together with the known stigmasterol, ursolic acid, 23-hydroxyursolic acid (3), and 3beta-hydroxylup-20(29)-en-28-oic acid. On the basis of their spectroscopic data and on chemical transformations, the structures of the new saponins have been established as 3-O-(alpha-Ll-arabinopyranosyl)-23-hydroxyursolic acid (1) and 3-O-(beta-D-glucopyranosyl)-23-hydroxyursolic acid (2). In a nitric oxide (NO)-production bioassay, compound 3 exhibited significant NO inhibitory activity, while compounds 1 and 2 were less potent than 3.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Araliaceae / chemistry*
  • Cameroon
  • Cells, Cultured / drug effects
  • Macrophages / drug effects
  • Mice
  • Molecular Structure
  • Nitric Oxide / antagonists & inhibitors*
  • Plant Bark / chemistry
  • Plant Leaves / chemistry
  • Plants, Medicinal / chemistry*
  • Saponins / chemistry
  • Saponins / isolation & purification*
  • Saponins / pharmacology*
  • Stereoisomerism
  • Triterpenes / chemistry
  • Triterpenes / isolation & purification*
  • Triterpenes / pharmacology

Substances

  • 3-O-(alpha-L-arabinopyranosyl)-23-hydroxyursolic acid
  • 3-O-(beta-D-glucopyranosyl)-23-hydroxyursolic acid
  • Saponins
  • Triterpenes
  • Nitric Oxide