Abstract
Two new triterpenoid saponins (1 and 2) were isolated from the stem bark of Cussonia bancoensis together with the known stigmasterol, ursolic acid, 23-hydroxyursolic acid (3), and 3beta-hydroxylup-20(29)-en-28-oic acid. On the basis of their spectroscopic data and on chemical transformations, the structures of the new saponins have been established as 3-O-(alpha-Ll-arabinopyranosyl)-23-hydroxyursolic acid (1) and 3-O-(beta-D-glucopyranosyl)-23-hydroxyursolic acid (2). In a nitric oxide (NO)-production bioassay, compound 3 exhibited significant NO inhibitory activity, while compounds 1 and 2 were less potent than 3.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Araliaceae / chemistry*
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Cameroon
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Cells, Cultured / drug effects
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Macrophages / drug effects
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Mice
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Molecular Structure
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Nitric Oxide / antagonists & inhibitors*
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Plant Bark / chemistry
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Plant Leaves / chemistry
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Plants, Medicinal / chemistry*
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Saponins / chemistry
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Saponins / isolation & purification*
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Saponins / pharmacology*
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Stereoisomerism
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Triterpenes / chemistry
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Triterpenes / isolation & purification*
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Triterpenes / pharmacology
Substances
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3-O-(alpha-L-arabinopyranosyl)-23-hydroxyursolic acid
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3-O-(beta-D-glucopyranosyl)-23-hydroxyursolic acid
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Saponins
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Triterpenes
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Nitric Oxide