Abstract
As shown by quantitative (1)H NMR measurements, a lipophilic extract of the aerial parts of Hypericum atomarium ssp. degenii contained a high percentage (3.1% per weight of dried plant material) of a prenylated phloroglucinol (1). Compound 1, named hyperatomarin, occurring in two tautomeric forms (1a <==> 1b), was isolated by bioactivity-guided preparative TLC and was identified on the basis of spectral data interpretation. This isolated phloroglucinol exhibited activity against Gram-positive (Staphyloccocus aureus and Microccocus luteus) and Gram-positive spore-forming bacteria (Bacillus subtilis and B. IP 5832).
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Anti-Infective Agents / chemistry
-
Anti-Infective Agents / isolation & purification*
-
Anti-Infective Agents / pharmacology
-
Bacillus subtilis / drug effects
-
Gram-Positive Bacteria / drug effects*
-
Hyperbaric Oxygenation
-
Hypericum / chemistry*
-
Microbial Sensitivity Tests
-
Micrococcus luteus / drug effects
-
Molecular Structure
-
Phloroglucinol / analogs & derivatives
-
Phloroglucinol / chemistry
-
Phloroglucinol / isolation & purification*
-
Phloroglucinol / pharmacology
-
Plants, Medicinal / chemistry*
-
Siberia
-
Staphylococcus aureus / drug effects
Substances
-
Anti-Infective Agents
-
hyperatomarin
-
Phloroglucinol