Hyperatomarin, an antibacterial prenylated phloroglucinol from Hypericumatomarium ssp. degenii

J Nat Prod. 2003 Sep;66(9):1236-8. doi: 10.1021/np030131o.

Abstract

As shown by quantitative (1)H NMR measurements, a lipophilic extract of the aerial parts of Hypericum atomarium ssp. degenii contained a high percentage (3.1% per weight of dried plant material) of a prenylated phloroglucinol (1). Compound 1, named hyperatomarin, occurring in two tautomeric forms (1a <==> 1b), was isolated by bioactivity-guided preparative TLC and was identified on the basis of spectral data interpretation. This isolated phloroglucinol exhibited activity against Gram-positive (Staphyloccocus aureus and Microccocus luteus) and Gram-positive spore-forming bacteria (Bacillus subtilis and B. IP 5832).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Infective Agents / chemistry
  • Anti-Infective Agents / isolation & purification*
  • Anti-Infective Agents / pharmacology
  • Bacillus subtilis / drug effects
  • Gram-Positive Bacteria / drug effects*
  • Hyperbaric Oxygenation
  • Hypericum / chemistry*
  • Microbial Sensitivity Tests
  • Micrococcus luteus / drug effects
  • Molecular Structure
  • Phloroglucinol / analogs & derivatives
  • Phloroglucinol / chemistry
  • Phloroglucinol / isolation & purification*
  • Phloroglucinol / pharmacology
  • Plants, Medicinal / chemistry*
  • Siberia
  • Staphylococcus aureus / drug effects

Substances

  • Anti-Infective Agents
  • hyperatomarin
  • Phloroglucinol