Photo-regulation of DNA function by azobenzene-tethered oligonucleotides

Hiroyuki Asanuma; Daijiro Matsunaga; Minghe Liu; Xingguo Liang; Jing Jhao; Makoto Komiyama

doi:10.1093/nass/3.1.117

Photo-regulation of DNA function by azobenzene-tethered oligonucleotides

Nucleic Acids Res Suppl. 2003:(3):117-8. doi: 10.1093/nass/3.1.117.

Authors

Hiroyuki Asanuma¹, Daijiro Matsunaga, Minghe Liu, Xingguo Liang, Jing Jhao, Makoto Komiyama

Affiliation

¹ Research Center for Advanced Science and Technology, The University of Tokyo, 4-6-1, Komaba, Meguro-ku, Tokyo 153-8904, Japan.

PMID: 14510408
DOI: 10.1093/nass/3.1.117

Abstract

Multiple azobenzene moieties were tethered to DNA on D-threoninol linker, and formation and dissociation of DNA duplex could be reversibly photo-regulated either by irradiating UV or visible light. With this photo-responsive DNA, RNase H reaction was also successfully photo-regulated.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Azo Compounds / chemistry*
Base Pairing
DNA / chemistry*
Light
Oligonucleotides / chemistry*
Photochemistry
Ribonuclease H / metabolism
Ultraviolet Rays

Substances

Azo Compounds
Oligonucleotides
DNA
Ribonuclease H
azobenzene