1,2,5,6-tetra-O-benzyl-D-mannitol derivatives as novel HIV protease inhibitors

Bioorg Med Chem Lett. 2003 Oct 20;13(20):3601-5. doi: 10.1016/s0960-894x(03)00677-2.

Abstract

The synthesis and structure-activity relationships of HIV protease inhibitors derived from carbohydrate alditols are discussed. We disclose a new series of 1,2,5,6-tetra-O-alkyl-D-mannitol exhibiting sub-micromolar activity against HIV-protease. This series of inhibitors are non-nitrogen containing HIV-protease inhibitors and they are readily prepared in a few chemical steps from inexpensive commercially available starting materials.

MeSH terms

  • Benzyl Compounds / chemical synthesis
  • Benzyl Compounds / chemistry*
  • Benzyl Compounds / pharmacology*
  • HIV Protease Inhibitors / chemical synthesis
  • HIV Protease Inhibitors / chemistry*
  • HIV Protease Inhibitors / pharmacology*
  • Mannitol / analogs & derivatives*
  • Mannitol / chemical synthesis
  • Mannitol / chemistry
  • Mannitol / pharmacology
  • Structure-Activity Relationship

Substances

  • Benzyl Compounds
  • HIV Protease Inhibitors
  • Mannitol