NBS-DMSO as a nonaqueous nonbasic oxidation reagent for the synthesis of oligonucleotides

Matthew C Uzagare; Kamlesh J Padiya; Manikrao M Salunkhe; Yogesh S Sanghvi

doi:10.1016/s0960-894x(03)00754-6

NBS-DMSO as a nonaqueous nonbasic oxidation reagent for the synthesis of oligonucleotides

Bioorg Med Chem Lett. 2003 Oct 20;13(20):3537-40. doi: 10.1016/s0960-894x(03)00754-6.

Authors

Matthew C Uzagare¹, Kamlesh J Padiya, Manikrao M Salunkhe, Yogesh S Sanghvi

Affiliation

¹ The Institute of Science, 15Madam Cama Road, Mumbai 400 032, India.

PMID: 14505665
DOI: 10.1016/s0960-894x(03)00754-6

Abstract

A new method for the oxidation of nucleoside phosphite triester into phosphate triester under nonbasic and nonaqueous conditions using NBS-DMSO in CH(3)CN has been developed. The utility of this method for solution- and solid-phase synthesis of oligonucleotide is demonstrated.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Chromatography, High Pressure Liquid
Dimethyl Sulfoxide / chemistry*
Indicators and Reagents
Magnetic Resonance Spectroscopy
Oligonucleotides / chemical synthesis*
Oxidation-Reduction

Substances

Indicators and Reagents
Oligonucleotides
Dimethyl Sulfoxide