We present a case of a 71-year-old male with exercise angina and two-vessel coronary artery disease (CAD). As the first step of treatment, the patient underwent successful coronary angioplasty with a stent implantation in the circumflex artery and remained free from angina for the following month. After this period, the patient underwent elective angioplasty of left anterior descending (LAD) coronary artery which was complicated by dissection, requiring implantation of two stents. Because of recurrent angina the patient underwent three months later another coronary angiography which revealed in-stent restenosis in LAD. The patient underwent repeated angioplasty with a good angiographic results, however, without cessation of angina Clinical and angiographic indications for percutaneous coronary interventions, according to the recent ACC/AHA guidelines, are discussed.