Intrahippocampal infusion of the bombesin/gastrin-releasing peptide antagonist RC-3095 impairs inhibitory avoidance retention

Peptides. 2003 Jul;24(7):1069-74. doi: 10.1016/s0196-9781(03)00179-7.

Abstract

Bombesin (BN)-like peptides regulate cell proliferation and cancer growth as well as neuroendocrine and neural functions. We evaluated the effects of the BN/gastrin-releasing peptide (GRP) antagonist RC-3095 on memory formation. Male Wistar rats were given a bilateral infusion of saline or RC-3095 (0.2, 1.0 or 5.0 microg) into the dorsal hippocampus either immediately or 2 h after training in an inhibitory avoidance (IA) task. Retention test trials were carried out 1.5 h (short-term memory) and 24 h (long-term memory) after training. RC-3095 impaired both short- and long-term retention only when given immediately after training. The results suggest that the hippocampal BN/GRP receptor system modulates IA memory formation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Avoidance Learning / drug effects*
  • Bombesin / administration & dosage
  • Bombesin / analogs & derivatives*
  • Bombesin / antagonists & inhibitors
  • Bombesin / pharmacology*
  • Catheterization
  • Dose-Response Relationship, Drug
  • Gastrin-Releasing Peptide / antagonists & inhibitors
  • Hippocampus / drug effects
  • Hippocampus / physiology*
  • Histocytochemistry
  • Infusion Pumps
  • Male
  • Memory / drug effects
  • Memory, Short-Term / drug effects
  • Peptide Fragments / administration & dosage
  • Peptide Fragments / pharmacology*
  • Rats
  • Rats, Wistar
  • Reaction Time / drug effects
  • Receptors, Bombesin / antagonists & inhibitors
  • Receptors, Bombesin / physiology*
  • Retention, Psychology / drug effects*
  • Time Factors

Substances

  • Peptide Fragments
  • Receptors, Bombesin
  • bombesin (6-14), Tpi(6)-Leu(13)-psi(CH2NH)-Leu(14)-
  • Gastrin-Releasing Peptide
  • Bombesin