Abstract
Bombesin (BN)-like peptides regulate cell proliferation and cancer growth as well as neuroendocrine and neural functions. We evaluated the effects of the BN/gastrin-releasing peptide (GRP) antagonist RC-3095 on memory formation. Male Wistar rats were given a bilateral infusion of saline or RC-3095 (0.2, 1.0 or 5.0 microg) into the dorsal hippocampus either immediately or 2 h after training in an inhibitory avoidance (IA) task. Retention test trials were carried out 1.5 h (short-term memory) and 24 h (long-term memory) after training. RC-3095 impaired both short- and long-term retention only when given immediately after training. The results suggest that the hippocampal BN/GRP receptor system modulates IA memory formation.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Avoidance Learning / drug effects*
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Bombesin / administration & dosage
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Bombesin / analogs & derivatives*
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Bombesin / antagonists & inhibitors
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Bombesin / pharmacology*
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Catheterization
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Dose-Response Relationship, Drug
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Gastrin-Releasing Peptide / antagonists & inhibitors
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Hippocampus / drug effects
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Hippocampus / physiology*
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Histocytochemistry
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Infusion Pumps
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Male
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Memory / drug effects
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Memory, Short-Term / drug effects
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Peptide Fragments / administration & dosage
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Peptide Fragments / pharmacology*
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Rats
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Rats, Wistar
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Reaction Time / drug effects
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Receptors, Bombesin / antagonists & inhibitors
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Receptors, Bombesin / physiology*
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Retention, Psychology / drug effects*
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Time Factors
Substances
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Peptide Fragments
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Receptors, Bombesin
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bombesin (6-14), Tpi(6)-Leu(13)-psi(CH2NH)-Leu(14)-
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Gastrin-Releasing Peptide
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Bombesin