Chronic neutrophilic leukemia (CNL) with karyotypic abnormalities associated with plasma cell dyscrasia: a case report

Haematologica. 1992 May-Jun;77(3):277-9.

Abstract

A case of chronic neutrophilic leukemia (CNL), a rare myeloproliferative syndrome associated with monoclonal gammopathy of uncertain significance (MGUS-Type IgGk), is reported. Karyotypic study, carried out on bone marrow, excluded Philadelphia-pos. chronic myeloid leukemia (CML) and showed Y loss (45 XO). Only a few cases of CNL with paraproteinemia have been reported, but no case of associated karyotypic abnormalities and paraproteinemia has so far been described.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Aged
  • Chromosome Deletion*
  • Humans
  • Immunoglobulin G / blood*
  • Immunoglobulin kappa-Chains / blood*
  • Karyotyping
  • Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative / complications*
  • Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative / genetics
  • Leukemia, Neutrophilic, Chronic / complications*
  • Leukemia, Neutrophilic, Chronic / genetics
  • Male
  • Paraproteinemias / etiology*
  • Y Chromosome*

Substances

  • Immunoglobulin G
  • Immunoglobulin kappa-Chains