During the past year, transplantation scientists have continued the quest for their version of the Holy Grail, developing and expanding model systems aimed at improving allograft survival. The highlights include further analyses of tolerance induction by intrathymic inoculation of allogeneic tissue, the use of oral tolerance to MHC antigens to improve graft survival, and expansion of the model of bone marrow transplantation to achieve solid organ tolerance in a large animal model and humans. Immunogeneticists have provided data on improved graft survival when MHC matching was performed at the molecular level.